>>Stop the run for a fifth game in a row. The Browns’ defense has a remarkable streak of run-stuffing going, and it can’t stop now. The Bills have a pair of high-impact running backs in C.J. Spiller and Fred Jackson, but both are hurting. Spiller is questionable with an ankle injury and Jackson is probable with a sore knee. The Browns cannot allow the Bills to find a way to move the ball on the ground, and that seems likely given how stout defensive linemen
>>The pass rush has to make the rookie quarterback feel like a rookie. It won’t be easy, because Manuel has mostly shown exceptional poise through the first four starts of his career. He is big, strong, and runs well. The Browns’ front seven will have to focus on containment, keeping Manuel in the pocket as often as possible. Defensive coordinator Ray Horton will look to confuse the rookie with a variety of blitzes and coverages. With outside linebackers
>>The offensive line needs to hold up against a strong front seven. The Browns and Bills have something in common: a highly aggressive and effective defensive front. The Browns’ offensive line played its best game of the season last Sunday against Cincinnati. It protected Hoyer well for the most part, although it still shows some vulnerability at the guard spots. The Bills have a dominant inside rusher in tackle Marcell Dareus, who usually commands double teams, and a dynamic outside rusher in end Mario Williams, who is probable with an ankle injury. Defensive tackle Kyle Williams, who is probable with an Achilles injury, is a classic inside plugger.
>>The 12th Man has to come up big. The crowd can be a definite factor in this game. Given that the Browns are on a two-game winning streak and that it has been a long time since there was a prime-time game at FirstEnergy Stadium and that the team will stage a dramatic ceremony honoring Jim Brown, the atmosphere should be electric. And if the Browns are able to get an early lead and keep the fans engaged, that should go a long way toward making things difficult for Manuel, who is getting his first taste of an NFL prime-time game.
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