Defensive back Joe Haden and kicker Patrick Murray were added to the injury report Friday and both are considered questionable for Sunday's game at Miami.
Their injuries are the latest to hit a Browns roster that already will be without five starters against the Dolphins. Quarterback Josh McCown (shoulder/clavicle), wide receiver Corey Coleman (hand), defensive lineman Carl Nassib (hand), safety Ibraheim Campbell (hamstring) and center Cameron Erving (bruised lung) were ruled out following Friday's walk-through.
Quarterback Robert Griffin III was placed on the injured reserve list last week with a broken shoulder bone.
Browns coach Hue Jackson said the rash of injuries, which comes one week after the team had an empty injury report entering the Ravens game, hasn't hampered the team's confidence as it embarks on a stretch of four road games over the next five weeks.
"I haven't sensed one guy that's fallen off the boat," Jackson said. "These guys are working hard. We know we have a big game this week. Again, I give a lot of that credit to our veteran players. Those guys have done a great job in the locker room.
"We've done a good job of making sure that our guys understand that next week's another opportunity. I think that's what this is all about. It's still so early in the season. We're just heading into Week 3. Like I said, we're just starting out. We have a long way to go."
Haden, who had two interceptions in last week's loss to the Ravens, is dealing with an injured groin, but Jackson doesn't anticipate it to be an issue. In the event Haden weren't able to play against Miami, veteran Tramon Williams Sr. or rookie Tracy Howard could be up for a significant increase in snaps and responsibility.
"We would have to look at our team and just see exactly where we are," Jackson said. "We've had quite a few guys back there practicing. Like I said, Joe was at practice yesterday and obviously, these things spring up. Again, we will see where we are.
Murray was added to the injury report after Friday's walk-through. The Browns do not have another kicker on the 53-man roster and would be potentially in position to make a move before Sunday.
"We'll see," Jackson said. "But we're doing good. We're moving forward."
Campbell's injury opens the door for rookie Derrick Kindred to make his first NFL start. The fourth-rounder out of TCU played the majority of snaps in last week's game and has 11 tackles over his first two games.
"I am hoping from him that he takes that quantum leap of, 'OK, I played some in Philly, I played some last week. I'm getting more and more reps,' and again for him that self-acknowledgement that 'I belong in this league. I can play. I am going to start this weekend. Let me go play,'" Browns defensive coordinator Ray Horton said. "There is no reason that he can't have a great game and go, 'Guys I can play in this league. Just let me, give me more and more snaps.'"
Defensive linemen Danny Shelton (knee) and Stephen Paea (elbow) and tight end Randall Telfer (neck), all of whom were on the injury report at the start of the week, are expected to play against the Dolphins.