If recent history tells us anything about the No. 12 pick, the Browns face an opportunity to land a player who can provide immediate contributions as a rookie and even bigger things in the years to come.
Of the 12 players selected at No. 12 since 2003, half have made at least one Pro Bowl appearance and a handful have served as key cogs on Super Bowl-winning teams. Others, as is the case with pretty much every spot in the first round, simply didn't live up to the expectations that come with going 12th overall.
Here's our breakdown of the past 12.
2007: Buffalo Bills - RB Marshawn Lynch
Rookie contributions: He started and appeared in 13 games, running for 1,115 yards and seven touchdowns.
What now?: Arguably one of the NFL's top running backs and most notable figures, Lynch is entering his sixth season with the Seattle Seahawks. He's made the Pro Bowl five times, won a Super Bowl and racked up 8,695 yards and 71 touchdowns over nine seasons.
2008: Denver Broncos - T Ryan Clady
Rookie contributions: He started all 16 games and was considered one of the NFL's top-performing rookies.
What now?: Entering his eighth season with the Broncos, Clady's appeared in four Pro Bowls, been named a first-team All Pro twice and started 98 games.
2006: Baltimore Ravens - DT Haloti Ngata
Rookie contributions: He got involved with the Ravens' defense right away, starting all 16 games and finishing with 31 tackles.
What now?: After nine seasons with the Ravens (five Pro Bowl), Ngata is now with the Lions after Baltimore dealt him for a draft pick.
2005: San Diego Chargers - OLB Shawne Merriman
Rookie contributions: Merriman started 10 games and appeared in 15 during a rookie season in which he finished with 57 tackles and two forced fumbles.
What now?: Merriman's last season in the NFL was an injury-shortened 2012 with the Buffalo Bills. He made three straight Pro Bowls (2005-07) during his prime.
2004: New York Jets - LB Jonathan Vilma
Rookie contributions: He piled up 107 tackles and three interceptions on his way to winning the 2004 AP Defensive Rookie of the Year.
What now?: The 10-year pro made three Pro Bowls and piled up 871 tackles during his NFL career. He last played in 2013.
2014: New York Giants - WR Odell Beckham
Rookie contributions: Despite missing four games, Beckham reeled off 91 catches for 1,305 yards and 12 touchdowns -- a number of which were highlight-reel plays -- en route to landing in the 2015 Pro Bowl.
What now?: Already considered one of the NFL's top wide receivers, Beckham carries sky-high expectations entering his second season.
2012: Philadelphia Eagles - DT Fletcher Cox
Rookie contributions: He appeared in 15 games and started nine while compiling 32 tackles and a forced fumble.
What now?: Cox has started 32 consecutive regular season games and is considered a core piece in the center of Philadelphia's defense.
2013: Oakland Raiders - CB D.J. Hayden
Rookie contributions: He played in eight games, starting two, while picking up 25 tackles, two passes defensed and an interception. The Raiders traded out of No. 3 and dropped back to 12 to pick Hayden, who was sidelined with a back injury for most of his rookie year.
What now?: Hayden's second season was marred by an injury, too, as he missed the first seven games of 2014 with a broken foot. He rebounded for the second half of the season, though, as he started eight games and played a key role on the Raiders' defense.
2010: San Diego Chargers - RB Ryan Mathews
Rookie contributions: He started nine games and appeared in 12 in an injury-shortened rookie season. Mathews finished 2010 with 678 yards and seven touchdowns.
What now?: After compiling more than 4,000 rushing yards, 1,110 receiving yards and 24 touchdowns over four seasons, Mathews signed with the Eagles, where he'll team with DeMarco Murray.
2009: Denver Broncos - RB Knowshon Moreno
Rookie contributions: He appeared in 16 games and started nine while running for 947 yards and seven touchdowns.
What now?: Moreno is a free agent after appearing in just three games with the Miami Dolphins last season. For his career, he has 3,616 rushing yards and 27 touchdowns.
2011: Minnesota Vikings - QB Christian Ponder
Rookie contributions: He started 10 games and went through some understandable rookie struggles, completing 54.3 percent of his passes for 1,853 yards, 13 touchdowns and 13 interceptions.
What now?: Ponder started every game in 2012 but fell out of favor in Minnesota because of his inconsistent play. After starting just one game in 2014, Ponder left the Vikings for Oakland, where he's backing up Derek Carr.
2003: St. Louis Rams - DT Jimmy Kennedy
Rookie contributions: He appeared in 13 games but didn't start any, finishing with two tackles.
What now?: Kennedy last saw the field in 2011. He started 30 games with the Rams from 2004-06 before bouncing around with a number of different teams.