The Browns will be without defensive end Emmanuel Ogbah for Thursday night's game against the Jets, and the statuses of several other starters remain up in the air.
Cleveland on Wednesday officially ruled out Ogbah (ankle) and tight end Seth DeValve (hamstring) while linebacker Christian Kirksey (shoulder/ankle) is listed as doubtful.
Wide receiver Jarvis Landry (knee) and free safety Damarious Randall (heel) are also questionable to play.
Ogbah, Kirksey and DeValve all missed Sunday's loss to the Saints while Landry and Randall joined the injury report this week. Both were limited in practice after seeing significant action in New Orleans.
Landry, a three-time Pro Bowler whom the Browns acquired in a trade with the Dolphins, headlines a receivers group that traded away Josh Gordon on Monday to the New England Patriots.
If he can't play, Cleveland will heavily lean on rookie Antonio Callaway (who's now starting in place of Gordon), third-year receiver Rashard Higgins, rookies Damion Ratley and undrafted free agent Derrick Willies.
Randall, a former first-round pick acquired in a trade with the Packers, has recorded an interception, four pass breakups and 10 tackles in two games.
Ogbah, who sustained an ankle injury in the season opener against the Steelers, is being evaluated on a week-by-week basis; Kirksey, the veteran captain, missed the first game of his career last weekend; DeValve, the third-year tight end, was added to the injury report last Saturday. He missed most of training camp with a quadriceps injury.