The Browns fell, 38-24, to the Cardinals on Sunday afternoon at State Farm Stadium after Arizona buried the Cleveland defense with an array of chunk plays through the air and on the ground.
Cleveland dropped to 6-8 with its second loss in its last three games.
Here are six plays that changed the game:
1. Kenyan Drake's opening-drive touchdown
The Browns defense struggled to contain Arizona quarterback Kyler Murray from the start. The Cardinals opened the game with a nine-play, 90-yard drive that ended with Murray pitching the ball to Drake from the 5-yard line for a walk-in score and 7-0 lead.
Murray went 4-for-4 with 52 yards, 42 of which went to wide receiver Larry Fitzgerald on three completions. The quick score also foreshadowed a long day for the Browns defense, who never put a full stop to the problems that arose in a rough first quarter.
2. Patrick Peterson intercepts Baker Mayfield
The pass, thrown from Arizona's 20-yard line, was overthrown and fell into the hands of Patrick Peterson, ending a promising first drive that kept the Browns down 7-0 early in the first quarter.
It was also Mayfield's 17th interception of the season and fifth in his last four games.
3. Drake punches it in from 1 yard out
The Browns couldn't have gotten off to a much tougher start.
Arizona took a 14-0 lead with 12 minutes left in the second quarter when Drake took a handoff from the 1-yard line for another easy score, his second touchdown of the day. That concluded a six-play, 67-yard Cardinals drive that featured plenty of missed assignments and broken tackles — including a 35-yard scramble from Murray.
The Browns had no solutions to stop the Cardinals, and their struggles on the offensive side of the ball put more importance on the defense to correct their first half mistakes.
Check out photos of the Browns in action against the Cardinals
4. Murray hits Arnold with a touchdown to end second quarter
The Browns stopped the bleeding and cut the score to 14-10 midway through the second quarter, but they couldn't end the half without giving up another touchdown.
Arizona put together a grueling 11-play, 87-yard drive that ended with Murray tossing a perfect pass to the corner of the end zone to tight end Dan Arnold for a 6-yard score.
That put the Cardinals up, 21-10, and gave the Browns plenty of work to do on both sides of the ball for a second half comeback. The Browns gave up 299 total yards of offense in the first half, which was more than the Cardinals have accrued in six full games this season.
5. Drake puts the Cardinals back up two scores after DPI challenge
Just when the Browns appeared to swing momentum, the Cardinals turned things around and got what they needed.
Arizona moved deep into Cleveland territory when referees overturned a no-call ruling of passing interference on safety Damarious Randall, who deflected a pass thrown to Christian Kirk in the Browns end zone. The Cardinals handed it off to Drake on the next play for another 1-yard touchdown.
That put the Cardinals up 28-17 over the Browns, who hadn't seen too many passing interference challenge reviews overturned this season. The trend changed at a bad time, though, and the Browns couldn't make the goal line stop.
6. Drake's fourth touchdown of the game
This one sealed it.
With seven minutes left, Drake hit a gap on the right side of the field and exploded for a 17-yard touchdown that put the Cardinals up 35-17. That was his fourth touchdown of the afternoon, and it all but cemented the Browns' eighth loss of the season.
It also showed the fatigue from the Browns defense, which struggled to wrap up Kyler Murray both on the ground and through the air. Murray didn't have the touchdowns to show for it, though.
Those went to Drake, and Cleveland couldn't stop him on this day.